The investigational glucose-dependent insulinotropic polypeptide/Medic GLP Support-1 receptor agonist tirzepatide led to significant and superior HbA1c and body weight reductions for adults with type 2 diabetes vs. SURPASS-2 study data show. Additionally, a prespecified exploratory analysis showed 60% of participants on the highest, 15-mg dose of tirzepatide (Eli Lilly) achieved a composite endpoint of an HbA1c of 6.5% or lower and weight loss of 10% or greater with no reports of severe hypoglycemia, compared with 22% of participants assigned 1 mg semaglutide (Ozempic, Novo Nordisk). "The results of the trial demonstrate that tirzepatide provided a degree of efficacy with respect to HbA1c lowering and reduction in body weight that has not previously been seen in clinical trials assessing antihyperglycemic agents," Juan Pablo Frias, MD, FACE, medical director and a principal investigator of the National Research Institute in Los Angeles, told Healio. For the phase 3 trial, Frias and colleagues analyzed data from 1,879 adults with type 2 diabetes inadequately controlled with metformin therapy of at least 1,500 mg daily (mean age, 57 years; mean baseline HbA1c, 8.28%; mean baseline weight, 93.7 kg).
Researchers randomly assigned participants a once-weekly subcutaneous injection of 5 mg, 10 mg or 15 mg tirzepatide or 1 mg semaglutide for 40 weeks, followed by a 4-week safety follow-up period. Primary endpoint was change in HbA1c from baseline to 40 weeks. The findings were presented as a late-breaking poster presentation and simultaneously published in The New England Journal of Medicine. Researchers found the estimated mean change from baseline in the HbA1c level was -2.01 percentage points, -2.24 percentage points and -2.3 percentage points with the 5 mg, 10 mg and 15 mg doses of tirzepatide, respectively, and -1.86 percentage points with semaglutide. The estimated differences between the 5 mg, 10 mg and 15 mg tirzepatide groups and the semaglutide group were -0.15 percentage points (95% CI, -0.28 to -0.03), -0.39 percentage points (95% CI, -0.51 to -0.26) and -0.45 percentage points (95% CI, -0.57 to -0.32), respectively. At all doses, tirzepatide was noninferior and superior to semaglutide. Reductions in body weight were greater with tirzepatide vs.
Science continues to prove that the old adage "you are what you eat" is profoundly true. This is because you have trillions of microorganisms living in your gut, which are directly responsible for nearly every aspect of your health. These microbes make up what’s called your "gut microbiota." They are especially influential in determining your likelihood of gaining excessive weight, becoming obese, and developing obesity-related diseases like diabetes, heart disease, supplement for a balanced lifestyle and premature death. The gut microbiome (the expressed genes of your gut microbiota) plays a major role in your metabolism through energy production, storage, and expenditure. So, it’s no surprise that science has found a strong connection between gut microbiome imbalance and metabolic syndrome. Yikes! If you have the wrong mix of microbes, it could be making it tough for you to get your health on track! Did you know: Scientists can actually look at your gut microbiome composition and MedicGLP tell with 90% accuracy if you are obese or lean. That’s pretty impressive, isn’t it?
1. Unable to lose weight and keep it off? 2. Struggling to fight cravings? 3. Sick of starving yourself for weight loss? 4. Baffled as to why no diet seems to really work for you? Depending on the composition of your gut microbiome, your microbes can either boost your health or weigh you down (figuratively and literally). The good news is this: You have control over these little guys with every bite you eat. Diet has the power to change the landscape of your gut microbiome. So, if you’ve tried multiple diets and can’t seem to get the results you want, it’s time to look into your gut microbiome.Will You Lose Weight Naturally on an Individualized Diet? If you’ve been struggling to lose weight and keep it off - it could be your gut microbiome. While Viome doesn’t guarantee weight loss, it has been an exciting result many of our customers have reported. "Fiona’s update day 37!